Though she was well -known as a miniature painter of considerable reputation, her early years and artistic training remain a mystery. She was born Clarissa Peters in February 1809 in North Andover, Massachusetts, situated twenty-four miles north of Boston. She was the fifth of twelve children born to Elizabeth Farrington Davis and John Peters. The Peters family had been prominent in local affairs for generations, and her father served as chairman of the board of selectmen. Clarissa most likely attended Franklin Academy, the first incorporated institution in Massachusetts to admit young ladies and the same school her younger sister Emily attended from 1836 to 1838.

By 1835 Clarissa Peters was in Boston not only painting miniatures but giving private instruction in the art as well. It is believed that Peters learned her profession from Moses B. Russell. Where and when they first met is unknown, but their careers as fellow miniaturists were intertwined. In 1839 Clarissa Peters was married to Moses Baker Russell (1809-1884) in Providence, Rhode Island. They had one son, Albert Cuyp Russell (1839-1917), who became a wood engraver.

Mrs. Russell's active participation in local exhibitions, which also included the Boston Athenaeum (1842, 1843, and 1844) and the Boston Artists Association (1842 and 1843), made her known to potential customers and obviated the need for paid advertisements. From 1840 to 1851 she shared a studio with her husband at 21 School Street in Boston. Mrs. Russell's work has often been confused with that of her husband, which is not surprising, given his tutelage, their exhibitions at the same locations, their occasional joint exhibitions of works under his name only, and the fact that the backing papers on a few of her pieces are inscribed simply "M.B. Russell." Although his influence shows in her work, his work is easily distinguishable from hers on the basis of palette, execution, formality, and subject matter. His infrequent renderings of children have a certain solemnity and lack the sympathy and vibrancy of hers.

Given the number of examples that have survived, it is apparent that Mrs. Russell clearly developed a specialty in children's portrait miniatures and mourning portraits. She was also skilled in her renderings of adults, but it is her depictions of childhood that captivate and charm . . . timeless tributes to innocence from an age that revered and celebrated the child. The over-sized limpid blue eyes of the sitter, the frontal pose of the head and shoulders, and the sitter's placement close to the picture plane create a sense of immediacy that fully engages and holds the viewer. Many of the characteristics we associate with Mrs. Russell's work are present in this portrait. These include the background, here a blend of purple, brown, and yellow, a kind of heavy sunset background that appears in a lot of her miniatures. The sky-like opening gives the work an atmospheric effect and creates the illusion of depth, counterbalancing the flat features of the subject. The eyelids and irises are heavily outlined, making the eyes the most prominent facial feature. The child exudes a sense of animation and good health, with pink cheeks and an intense gaze. The overlarge eyes create an emotional connection between subject and viewer, as is the case in many of Mrs. Russell's portraits. By contrast the mouth seems pinched, set off by small marks at each corner with a shadow below the lower lip. Upon close scrutiny one can see that the hairs of the eyebrows are individually delineated as are the blonde ringlets that frame the face.  This is an exceptional example of the work of Mrs. Moses B. Russell.